Monocyte Activation Test Mat

Mat is a non animal alternative to the traditional rabbit pyrogen test and we are pleased to have introduced it as part of our commitment to the reduction refinement and replacement of animal testing. In particular scientists have focused on the development and validation of in vitro tests 9 11 12 such as recombinant factor c rfc test and monocyte activation test mat. The mat offers significant advantages over animal testing.

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Monocyte activation test mat.

The mat test or the monocyte activation test is capable enough to detect both non endotoxin and endotoxin pyrogens in one single test. Monocyte activation test to reliably measure the pyrogenic content of a vaccine. Mats use an elisa assay to measure cytokine release from treated blood cells. The mat is suitable after product specific validation as a replacement for the rpt.

At nibsc a monocyte activation test mat was adapted and validated as an alternative. The mat allows the detection of the full range of pyrogens including endotoxins and non endotoxin pyrogens neps. Sot 2019 annual meeting 2. Monocyte activation tests mats are human cell based tests to detect and quantify pyrogens.

Two mat systems for pyrogen testing including endotoxin and non endotoxin pyrogen nep detection. Backed by several regulatory bodies this strong mat test. Monocyte activation test mat reliably detects pyrogens in parenteral formulations of human serum albumin. Supported by many regulatory bodies the robust mat assay produces sensitive results based on the human immune reaction.

Monocyte activation test the mat is used to detect or quantify substances that activate human monocytes or monocytic cells to release endogenous mediators which have a role in the human fever response. The ctl mat monocyte activation test kit of mat biotech acts as a key tool in helping teams dealing with low endotoxin recovery ler effects while using lal or rfc due to its uniquely low susceptibility to interfering factors. This required setting of a specification in house and deciding on a decisional procedure using multiple donors allowing batches equally pyrogenic or less than those batches shown to be safe in a clinical trial to be certified as safe. The monocyte activation test mat is the assessment of pyrogenicity of pharmaceutical products and medical devices.

The monocyte activation test mat can detect both endotoxin and non endotoxin pyrogens in one test. Being aware of these limitations of the rpt and lal when applied to bexsero the monocyte activation test mat which is sensitive to both endotoxin and non endotoxin based pyrogens has been developed as an alternative pyrogen test. Perdomo morales r pardo ruiz z spreitzer i lagarto a montag t.